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Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers (Springer Theses)

Janet T F Lau




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 |  Janet T F Lau |  2015-08-08 | Original language:English | PDF # 1 |  9.21 x.43 x6.14l,.64 | File type: PDF | 180 pages

 | Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine based Photosensitizers Springer Theses

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Janet Lau's thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but ...

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