[PDF.22la] Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 (Springer Theses)

Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 (Springer Theses)

[PDF.bo67] Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 (Springer Theses)

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 |  2014-08-09 |  2014-08-09 | Original language:English | PDF # 1 |  9.25 x.21 x6.10l,.33 | File type: PDF | 74 pages

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This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for prot...

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