[PDF.36in] Target Validation in Drug Discovery

Target Validation in Drug Discovery

[PDF.fm07] Target Validation in Drug Discovery

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 | #5051370 in Books |  Brian W Metcalf |  2006-10-06 | Original language:English | PDF # 1 |  10.00 x.69 x7.01l,1.81 | File type: PDF | 296 pages

 | Target Validation in Drug Discovery

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This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, whic...

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