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Computational Toxicology: Chapter 4. Modeling of Sensitive Subpopulations and Interindividual Variability in Pharmacokinetics for Health Risk Assessments

Kannan Krishnan, Brooks McPhail, Weihsueh Chiu, Paul White




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Many health risk assessments develop exposure limits for chemicals, intended to protect the general population, including sensitive subpopulations. Critical toxicokinetic and toxicodynamic determinants of toxicity vary among subgroups of populations, thus making some of them potentially more susceptible than the general population to the health effects of chemicals. This chapter focuses on toxicokinetics and reviews the current computational approaches to address the iss...

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